PTTG1Pituitary Tumor Transforming Gene-1
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The inventive method involves the use of a pituitary tumor transforming gene (PTTG)2 peptide, which has the ability to regulate endogenous PTTG1 expression and/or function in a dominant negative manner.
Ccne1, Ccnb1, Pttg1, and Nek6 mRNAs were strongly upregulated, while expression of Ccnd1 mRNA during the examined period was comparable to the control.
There are several important mitosis restriction points, for example, formation of metaphase in equatorial plane or separation of sister chromatids during anaphase, in which Nek6 and Pttg1 genes play an important role.