PTWIProvisional Tolerable Weekly Intake
PTWIPre-Trial Witness Interview (UK)
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Reports suggest that lower levels of arsenic below PTWI levels were also associated with lung cancers.
The provisional tolerable weekly intake (PTWI) of lead set by the Joint FAO/WHO Expert Committee on Food Additives is 25 [micro]g/kgbw/week, and hence its tolerable daily intake (TDI) value is 3.6 [micro]g/kg bw/day [20].
Thus, the consumption of these grape juices represents a risk situation, since the estimated exposure to OTA (16.24 and 67.20ng [kg.sup.-1] bw [day.sup.-1] for adults and children, respectively) was higher than the PTWI (16ng [kg.sup.-1] bw [day.sup.-1]) defined as safe by JECFA.
Based on the results, PTWI for all the selected heavy metals were far below the tolerable intake stated by FAO/WHO with the exception of As with PTWI calculated, 14.68 pg/kg.
The PTWI of 1.6 pg per kg of body weight established by the JECFA would translate to almost 100 pg of mercury for a female adult weighing about 60 k, or weekly consumption of 200 g of fish with a mercury concentration of 0.50 ppm.
Subsequently, weekly intake values were compared with the provisional tolerable weekly intake (PTWI) values established by the World Health Organization standards.
For all population subgroups, the lead, cadmium, and mercury exposure was lower than the provisional tolerable weekly intake (PTWIs) for lead (25 [micro]g/kg body weight/week [bw/w]), cadmium (2.5 [micro]g/kg bw/w), and mercury (5 [micro]g/kg bw/w), respectively (European Food Safety Authority, 2009; WHO, 1999, 2003).
Hence, the Joint Food and Agricultural Organization (FAO)-World Health Organization (WHO) Expert Committee on Food Additives established the provisional tolerable weekly intakes (PTWI) for adults of 7.0 mg Al kg[?]1 of body weight [15].
The Food and Agriculture Organization/World Health Organization (FAO/ WHO) Joint Expert Committee on Food Additives has defined the provisional tolerable weekly intake (PTWI) for a chemical with no intended function as an estimate of the amount of the chemical that can be ingested weekly over a lifetime without appreciable health risk.