In contrast, in PUUO at 9 and 15 weeks, COX-2 expression level was significantly increased in the obstructed kidneys (894% of sham level, p < 0.
The main results of the present study demonstrated the neonatally-induced PUUO in rats caused a significant decrease in urine osmolality and increased the abundance of urinary sodium in the obstructed kidney at 9 and 15 weeks after the onset of PUUO.
The results of the present study concurred that PUUO induced within 48 hours of life was associated with a marked urine osmolality reduction in the obstructed kidneys at 9 and 15 weeks after the onset of obstruction.
17] In the current study, PUUO led to a marked decrease in urine osmolality.
Thus, the observed changes at 9 and 15 weeks after the onset of obstruction may not reveal the immediate response to PUUO.
COX-2, not COX-1, in the obstructed kidney is upregulated in response to neonatally-induced PUUO.