PVNSPigmented Villonodular Synovitis
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PVNS is a benign and rare monoarticular disease occurring in the joints, characterized by a proliferation of synovial cells, effusions and bone erosions.
The pathology report revealed a typical appearance of PVNS, diffuse type [Figure 3] and [Figure 4].{Figure 2}{Figure 3}{Figure 4}
Pigmented villonodular synovitis (PVNS) is a rare proliferative disease that usually affects the synovial membrane of joints or tendon sheaths resulting in joint swelling and bone erosion, affecting 2.4% of cases the shoulder joint (1).
(3) PVNS is also a vascular lesion, but unlike synovial hemangioma, it contains deep stroma that are filled with proliferative histiocytes and multinucleated giant cells.
of Cases % Non-specific synovitis 22 73.3 Rheumatoid synovitis 3 10 Tuberculous synovitis 3 10 PVNS 1 3.3 Synovial chondromatosis 1 3.3 Others 0 0 Chart-2 Sex ratio male 3 female 27 Note: Table made from bar graph.
PVNS is a rare, locally aggressive tumor of the synovium, characterized by local over-expression of CSF-1, which recruits macrophages into the joints, forming the non-malignant tumor mass.
Methods: From September 2006 to August 2011, 28 diffuse PVNS patients were diagnosed and treated under arthroscopy.
Ao Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (bolsas de produtividade em pesquisa) e a Coordenacao de Aperfeicoamento de Pessoal de Nivel Superio (CAPES) (Edital 6/2012, PVNS).
Ao CNPq (Bolsa de Produtividade em Pesquisa), a Fundacao Araucaria (Bolsa de Produtividade em Pesquisa) e a CAPES (Edital 6/2012, PVNS).
There are instances where the clinical and imaging features are so typical that the biopsy may not be required, and it is possible to identify the nature of the soft tissue mass: lipoma, hemangioma, and neurofibroma for benign soft tissue tumors, ganglions and popliteal cysts, myositis ossificans, and PVNS for pseudotumors lesions [18].