Her research interests are the biology and pathogenesis of emerging human PyVs, and molecular diagnostic techniques and their application to virus detection.
A sole detection episode was defined as [greater than or equal to] 1 consecutive swab specimens in which an individual PyV was the only virus detected, and no other viruses were reported 7 days before or after detection of the PyV.
In addition to MCV, however, sequencing of the cloned rolling circle amplification (RCP) products also revealed the existence of two previously unknown PyVs, termed as HPyV6 and 7 (discussed below).
Leendertz and colleagues screened 597 clinical samples collected from immunocompromised (renal transplant, HIV-infected, and PML) individuals, having previously identified more than 20 novel PyVs in non-human primates .
However, recent reports suggest that another PyV
, BKV, can also cause a PML-like disease [47, 48].
The NCRR of RacPyV encodes multiple consensus pentanucleotide LT-Ag binding sites (GAGGC) on both strands as seen in other PyVs. RacPyV LT-Ag has 46% homology to MCPyV LT-Ag and has features conserved among PyV LT-Ags, including the LXCXE motif necessary for LT-Ag association with the retinoblastoma protein and the Walker A box GPXXXGKT, which suggests that RacPyV LT-Ag is an ATPase that binds to p53 (26).
In other PyVs, sT-Ag, which shares a start site with LT-Ag, promotes ceil transformation through negative regulation of the protein phosphatase 2A (PP2A) family of serine-threonine phosphatases (26,27).
In fact, HCST recipients might be more prone to productive infection with KIPyV and WUPyV than to infection with PyVs
JC and BK (BKPyV) (5).
) are highly prevalent, small DNA viruses, capable of persistence in the host.
may be merely transmitted through the respiratory route or detected during periods of reactivation (9).
Specimens positive for KIPyV or WUPyV were tested for adenoviruses; human bocavirus; human rhinoviruses; human metapneumovirus; human coronaviruses OC43, 229E, NL63, HKU1; and human PyVs
BK and JC by using PCR methods (6-11).
To the Editor: WU polyomavirus (WUPyV) is a recently described PyV
found in patients with acute respiratory tract infections (1).