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Patients with squamous cell carcinoma are still treated with either paclitaxel/carboplatin or gemcitabine with either carboplatin or cisplatin.
An increase in plasma exposure with paclitaxel/carboplatin was not associated with any change in birinapant tolerability.
However, Compared With Surveyed Oncologists, Surveyed MCO Pharmacy Directors Indicate Less Satisfaction With Paclitaxel/Carboplatin and Docetaxel/Cisplatin In Terms of Accessibility, According to Findings from Decision Resources
The findings from Decision Resources reveal that the highest proportion of surveyed MCO pharmacy directors (40 percent) indicate that paclitaxel/carboplatin is the most efficacious therapy for stage IB, II, and IIIA NSCLC.
However, compared with surveyed oncologists, surveyed pharmacy directors indicate less satisfaction with paclitaxel/carboplatin and docetaxel/cisplatin in terms of accessibility.
Study 041 is a multi-center, randomized, double blind, three arm trial evaluating the efficacy and safety of ipilimumab in combination with paclitaxel/carboplatin compared to paclitaxel/carboplatin alone in previously-untreated patients with Stage IIIb or IV non-small cell lung cancer (n=203).
Findings from a Phase 1 study of axitinib in combination with paclitaxel/carboplatin or gemcitabine/cisplatin in patients with advanced NSCLC and other solid tumors are being presented at ASCO.
The most common treatment-related adverse events for axitinib combined with either paclitaxel/carboplatin or gemcitabine/cisplatin were hypertension (34.
Now the chemotherapy in that Genentech (Study E4599) trial was slightly different, using paclitaxel/carboplatin, but with the chemotherapy control groups offering such similar survival rates, I think most oncologists will agree that Avastin is the superior first-line choice to Erbitux.
The primary objective of the Phase I/II study is to determine the safety and maximum tolerated dose of GRN163L when administered intravenously in combination with a standard paclitaxel/carboplatin regimen.