(1,2) There is an apparent association between the pathogenesis of MRSA strains and the expression of virulence factors such as cell surface components (e.g., collagen-binding protein, clumping factor, fibronectin-binding protein, and elastin-binding protein) and secreted factors (e.g., staphylokinase, toxic shock syndrome toxin-1, hemolysin, Panton-Valentine leukocidin
(PVL), exfoliative toxins (eta, etb), staphylococcal enterotoxins, and lipase).
All isolates were characterized for SCCmec types (I-V) and subtype of SCCmecIV (IVa, IVb, IVc and IVd), (4) agr polymorphism (I-IV), (5) and for the presence of 14 virulence genes, including nine enterotoxins (sea, seb, sec, sed, see, seg,seh, sei,sej), two exfoliatins (eta and etb), the toxic shock syndrome toxin (tsst), Panton-Valentine leukocidin
(pvl), and icaA.
A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin
gene: A case report in Japan.
Prevalence and sequence variation of panton-valentine leukocidin
in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains in the United States.
A history of panton-valentine leukocidin
(PVL)-associated infection protects against death in PVL-associated pneumonia.
Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin
. Lab Invest 2007;87:3-9.
(PVL) is one of the most important virulence factors of S.
However, it is associated with the production of virulence factors that contribute to complications, including Panton-Valentine leukocidin
(PVL), alpha-hemolysin, and the arginine catabolic mobile element (ACME) [5, 6].
(PVL) is a cytotoxin which causes leukocyte destruction and tissue necrosis.
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin
and highly lethal necrotising pneumonia in young immunocompetent patients.
aureus leukocidins responsible for lysis of human phagocytic (immune) cells: Panton-Valentine leukocidin
, leukocidin ED, and gamma-hemolysins AB and CB.