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References in periodicals archive ?
'There is still a high unmet medical need for the development of treatment methods when pathologic complete response (pCR) is not obtained by neoadjuvant therapy.
Although the absence of a p53 mutation in a tumor biopsy before treatment indicates that there is a predictive factor for a pathologic complete response (13), Esposito et al.
She underwent bilateral mastectomy with reconstruction in May 2013, and pathology revealed pathologic complete response (negative for malignancy in the breast; no further lymph node dissection was performed).
Surgical specimens were analyzed to define the pathologic complete response (pCR) as the absence of microscopic residual invasive cancers.
In patients with triple-negative breast cancer (TNBC) or BRCA-associated tumors, the incorporation of platinum agents increases pathologic complete response (pCR) rates and may be considered when neoadjuvant chemotherapy is indicated.
Results from the neoadjuvant efficacy phase of the study, including pathologic complete response assessed both by local investigators and also by independent pathology review, were presented last week during a poster discussion at the European Society for Medical Oncology 2017 Congress.
Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL-CALGB 150007/150012, ACRIN 6657.
(29) Masuda et al (32) showed that the BL1 subtype had the highest, and BL2 and LAR the lowest, pathologic complete response rates (52%, 0%, and 10%, respectively) when treated with neoadjuvant chemotherapy; however, despite having a low pathologic complete response rate, the LAR subtype had the best overall survival.
In the neoadjuvant setting, when associated with chemotherapy, trastuzumab significantly improved pathologic complete response, and reduced the risk of relapse, disease progression and death when compared to chemotherapy alone (4).
Al-Batran et al., "Impact of pathologic complete response on disease-free survival in patients with esophagogastric adenocarcinoma receiving preoperative docetaxel-based chemotherapy," Annals of Oncology, vol.
However, the rate of pathologic complete response (PCR) was significantly different (5% versus 30%).