Treatment with oral levofloxacin is safe and effective against bacteria in the middle-ear fluid of children with recurrent or persistent acute otitis media
, based on data from children aged 6 months to 5 years.
Widespread use of the 7-valent pneumococcal conjugate vaccine has resulted in a shift in frequency of causative bacterial pathogens responsible for recurrent and persistent acute otitis media
(AOM); disease management practice should encompass this change (SOR: B).
High-dose azithromycin versus high-dose amoxicillin-clavulanate for treatment of children with recurrent or persistent acute otitis media
He gave the example of a study he published in which patients with presumed persistent acute otitis media
received tympanocentesis to identify the bacteria (Pediatr.