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Related to Peutz-Jeghers syndrome: Lynch syndrome, Turcot syndrome
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References in periodicals archive ?
Wagner et al., "High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome," Gut, vol.
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome two years' treatment with anastrozole and genetic study.
The ACOG committee opinion identifies common hereditary cancer syndromes involved in gynecologic cancers, including hereditary breast and ovarian cancer syndrome and Lynch, Li-Fraumeni, Cowden, and Peutz-Jeghers syndromes.
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391 (6663):184-187.
Other factors may be patients with hereditary pancreatitis or patients with certain germline mutations in BRCA2, p16, or Peutz-Jeghers syndrome. Smoking is another important risk factor related to PC (relative risk, 3.7).
Look for spider angiomas and palmar erythema (as occur in cirrhosis); warm, moist skin and myxedema (as in Graves' disease); and mucocutaneous lentigines (as in Peutz-Jeghers syndrome).
(7,49) An additional advantage of cross-sectional imaging is the ability to screen for extraluminal malignancies that can arise in Peutz-Jeghers syndrome.
LKB1 is a serine/threonine protein kinase which was first discovered in the study of Peutz-Jeghers syndrome (Hemminki et al., 1998; Jenne et al., 1998).
The mucocutaneous pigmentation due to melanin deposition of Peutz-Jeghers syndrome is associated with increased morbidity from intestinal polyps and increased risk of invasive carcinoma.
DISTRIBUTION OF PATIENTS BY CLINICAL FEATURES, N=183 Main Comparative Clinical forms group group Solitary polyps 33 19 Multiple polyps 18 27 Diffuse polyposis 43 28 Out of them Peutz-Jeghers syndrome 9 2 Malignant polyposis 8 7 Distal part of intestine 70 65 Left side 12 6 Subtotal 3 4 Total 17 6 Villous polyps 14 9 Adenomatous 35 22 Adenopapillomatous 27 18 Hyperplastic 10 11 Proliferative 5 9 Cancer in situ 11 13 Complications Posthemorragic anemia 22 31 Cachexy 7 2 Strictures 6 3 Chronic colonic ileus 7 11 Malignization 10 5 Toxic dilatation of colon 2 1 Acute colonic ileus (intussusception) 3 5 Bleeding from rectum 35 32 Colonic perforation 1 1 TABLE 3.