Most large-scale manufacturers in Mexico now use a production process known as P-2-P (from the precursor chemical phenyl-2-propanone
In addition to the methods involving ephedrine, pseudoephedrine, and phenyl-2-propanone
(which itself can be synthesized in a variety of ways), methamphetamine can be made, for example, with methylamine and the amino acid phenylalanine.
Alpha-phenylacetoacetonitrile (APAAN) is used in amphetamine production and acetic anhydride is used as a pre-precursor for phenyl-2-propanone
Russia is a producer of several precursor chemicals including the amphetamine precursor benzyl methyl ketone (aka Phenyl-2-Propanone
or P2P), the heroin precursor Acetic Anhydride, and the precursor Gamma-butyrolactone (GBL), a precursor in the production of Gamma-hydroxybutyric acid (GHB).