in males and females in each age group were compared by use of unpaired t-tests.
Serum concentrations of PICP, PINP
, ICTP, and PIIINP were determined by specific RIAs based on human antigen (Orion Diagnostica) (1-3).
Quantification of the N-terminal propeptide of human procollagen type I (PINP
): comparison of ELISA and RIA with respect to different molecular forms.
was first isolated from antibiotic fluid under the name fetal antigen 2 (6), and amino acid sequencing identified the high-molecular weight form as a homomer of the a1 chains of PINP
A Chinese study reported a significant association between the blood PINP
levels and the BMD in post-menopausal women34.
Correlation analysis showed in the included patients the level of Apelin-13 was positively correlated to the value of BMD and PINP
(p<0.05), but negatively correlated to age and ICTP (p-2.5 and <-1.0 SD indicates osteopenia; T-score [greater than or equal to]-1.0 indicates normal.3 The included patients were divided into normal, osteopenia and osteoporosis group according to the outcome of BMD measurements.
The DSK supports both luminance (black/white) and chroma (blue/green) keying for compositing two video sources, plus the additional layer of PinP
, plus background video.
The serum levels of calcium, phosphorus, alkaline phosphatase (ALP), magnesium, thyroid-stimulating hormone (TSH), free thyroxine (f[T.sub.4]), parathyroid hormone (PTH), 25 hydroxycholecalciferol [25(OH)[D.sub.3]-Vitamin D], PINP
, TRACP 5b, and urine calcium/creatinine ratio were analyzed in the biochemistry laboratory of Baskent University.
Most notably, CTX, NTX, monomeric PINP
and OC display renal clearance and will generally be increased in renal insufficiency (31).
and CTX increased in the diet group (8.5 [+ or -] 6.2% and 35.8 [+ or -] 11.4%, resp.), decreased in the exercise group (-14.6 [+ or -] 5.5% and -13.4 [+ or -] 7.2%, resp.), and did not change in the diet-exercise group .
Jensen et al., "Procollagen type I N-terminal propeptide (PINP
) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism," Bone, vol.
Type I collagen could be assessed as biomarkers for the synthesis of the bone matrix by measuring N-terminal propeptides of type I procollagen (PINP
) and carboxyterminally cross-linked telopeptides (CTX) .