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References in periodicals archive ?
Among these DEGs, we found an alternative splicing forms in cordon-bleu WH2 repeat protein-like 1 (COBLL1), cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2), pleckstrin homology domain containing, family member 1 (PLEKHG1), and AXL receptor tyrosine kinase (AXL) genes [2].
van Aalten, "Binding of phosphatidylinositol 3,4,5 trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change," Biochemical Journal, vol.
Benner, "A prediction of the secondary structure of the pleckstrin homology domain," Proteins, vol.
Mikoshiba, "Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain," Biochemical and Biophysical Research Communications, vol.
Abbreviations: AM, alveolar macrophages; PA, Pseudomonas aeruginosa; GST, glutathione S transferase; YFP, yellow fluorescent protein; GFP, green fluorescent protein; PH, pleckstrin homology domain, Lyn, v-yes yamaguchi sarcoma related gene / protein; PI3K, phosphoinositol -3- kinase; Akt, protein kinase B; MHS, murine alveolar macrophage cell line from ATCC.
This amino acid substitution occurs within the pleckstrin homology domain in the amino-terminal region of the protein and is presumed to alter normal B-cell signaling by disrupting protein-protein interactions.
Especially, 581 genes that have Hanwoo-specific SNPs at least five are associated with immune activation by external stimuli, through epidermal growth factor-like domain (EGF-like domain), pleckstrin homology domain (PH domain), immunoglobulin subtype 2, and thrombospondin (Figure 3) (Chen et al., 2015).
(D) Epidermal growth factor-like domain (EGF-like domain), Pleckstrin homology domain (PH domain) and immunoglobulin subtype 2 have immune activation function from external stimuli.
In addition, alternative splicing forms of cytoplasmic dynein 1 (DYNCl), AXL receptor tyrosine kinase (AXL), pleckstrin homology domain containing, family G (with RhoGef Domain) member 1 (PLEKHG1), and the cordon-bleu WH2 repeat protein-like 1 (COBLL1) showed reversed expression patterns before and after exercise in skeletal muscle (Park et al., 2012).
These markers include adenylate cyclase 3 (ADCY3); diacylglycerol kinase, alpha (DGKA); family with sequence similarity 46, member A (FAM46A); immunoglobulin superfamily, member 4 (IGSF4), which also is known as cell adhesion molecule 1 (CADM1); KIAA1539; myristoylated alanine-rich protein kinase C substrate (MARCKS); proteasome activator subunit 1 (PSME1); Ras association and pleckstrin homology domains 1, also known as LPD (RAPH1); and intracellular Toll-like receptor 7 (TLR7).
Among the topics are inositol lipids and RTPC channel activation, pleckstrin homology domains and phospho-inositides, inositol polyphosphate kinases as regulators of nuclear function, and the evolution of the diverse biological roles of inositols.