(redirected from Poorly Differentiated Neuroendocrine Carcinoma)
PDNCProgressive Democrats of North Carolina (Efland, NC)
PDNCPuckapunyal and District Neighbourhood Centre (Australia)
PDNCPoorly Differentiated Neuroendocrine Carcinoma (cancer)
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An additional study by Shida et al (5) revealed that m/hASH1 was expressed in poorly differentiated neuroendocrine carcinoma, but was absent in gastroenteropancreatic carcinoids.
E, A small cell type of poorly differentiated neuroendocrine carcinoma with a high nuclear to cytoplasmic ratio, hyperchromatic nuclei, inconspicuous nucleoli, and nuclear molding.
These findings argue against the diagnostic value of using islet-1 to identify a pancreatic origin when dealing with a poorly differentiated neuroendocrine carcinoma.
Previous pathologic diagnosis varied and included the intermediate type of SC in 2 cases, mixed SC and LC in 1 case, high-grade AC in 1 case, and poorly differentiated neuroendocrine carcinoma in 1 case.
These 8 cases included 2 adenomas misdiagnosed as adenocarcinomas; a poorly differentiated neuroendocrine carcinoma of the anus, originally classified as a basaloid squamous cell carcinoma; a pancreatic adenocarcinoma, which was initially diagnosed as fat necrosis with a subsequent biopsy diagnosed as suggestive of mucinous cystic neoplasm; an overlooked cytomegalovirus infection in a colon biopsy; a colon biopsy diagnosed as acute and chronic inflammation, which was suggestive of chronic inflammatory bowel disease; an in situ squamous cell carcinoma of the anus, originally called microinvasive carcinoma; and a case of Helicobacter-associated chronic active gastritis, originally called an atypical lymphoid infiltrate.
Combination chemotherapy of etoposide plus cisplatin has been reported to be effective in poorly differentiated neuroendocrine carcinomas (12), with a response rate of 41.
Poorly differentiated neuroendocrine carcinomas and recurrent neuroendocrine tumors were not included in the study.
Only 8% of poorly differentiated neuroendocrine carcinomas of the larynx have been reported to metastasize to the central nervous system as a preterminal event.
Poorly differentiated neuroendocrine carcinomas (small-cell or oat-cell tumors) also occur in older men in the supraglottis; patients frequently have hoarseness, a neck mass, and a distant metastasis.
a) For poorly differentiated neuroendocrine carcinomas, the College of American Pathologists (CAP) checklist for carcinoma of the appendix1 should be used.
Poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and tumors with mixed glandular/ neuroendocrine differentiation are not included.
a) For poorly differentiated neuroendocrine carcinomas arising in the small intestine or ampulla, the College of American Pathologists (CAP) checklists for carcinomas of those organ sites (1,2) should be used.