PreSAPPrevention of Sporadic Adematous Polyps
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(8.) Arber N, Eagle CJ, Spicak J, et al., for the PreSAP trial investigators.
Trial names used in this review ADAPT: Alzheimer's Disease Anti-inflammatory Prevention Trial APC: Adenoma Prevention with Celecoxib APPROVe: Adenomatous Polyp Prevention on Vioxx CLASS: Celecoxib Long-term Arthritis Safety Study MEDAL programme: Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme PreSAP: Prevention of colorectal Spontaneous Adenomatous Polyps TARGET: Therapeutic Arthritis Research and Gastrointestinal Event Trial VIGOR: Vioxx Gastrointestinal Outcomes Research Table II.
"Both the APC and PreSAP studies were designed with high statistical power to assess the effect on polyp recurrence.
A third study that has not yet been published--the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial--found similar results in high-risk patients randomized to celecoxib, compared with placebo.