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Proenkephalin and prognosis after acute myocardial infarction.
Chen, "Circulating levels of neuropeptide proenkephalin A predict outcome in patients with aneurysmal subarachnoid hemorrhage," Peptides, vol.
Wang, "Intrathecal herpes simplex virus type 1 amplicon vector-mediated human proenkephalin reduces chronic constriction injury-induced neuropathic pain in rats," Molecular Medicine Reports, vol.
In order to address these questions, we tested the protein level of protein kinase C (PKC), MEK, and extracellular signal-regulated kinase 1/2 (ERK1/2) in the mGluR5 mediated PKC/MEK/ERK1/2 signaling pathway; we also tested the mRNA expression level of prodynorphin (PDyn) and proenkephalin (PEnk) in order to verify the effect of the blockade of mGluR5 on the direct and indirect pathways.
Calcium increase would stimulate the synthesis of proenkephalin (PENK) which, in turn, activates the [delta]-opioid receptor to reduce nociceptive response.
Ontogenesis of proenkephalin products in rat striatum and the inhibitory effects of low-level lead exposure.
* Met- and Leu-enkephalin are produced from the precursors proenkephalin A and B and prodynorphin; neurons that synthesize proenkephalin are widely distributed in brain.
Extinction of cocaine self- administration produces a differential time-related regulation of proenkephalin gene expression in rat brain.
Amount Funded: $46,962 (year 2 of 2) Chronic Neurogenic Pain After Spinal Cord Injury: Antinociception With Transplants of Galanin and Proenkephalin Secreting Cells Principal Investigators: Jeffrey Plunkett, Ph.D., Post-Doctoral Fellow; Robert Yezierski, Ph.D., Senior Investigator The Miami Project to Cure Paralysis, University of Miami Miami, Fla.
PCR BASED EVIDENCE FOR TWO SIMULTANEOUSLY EXPRESSED PROENKEPHALIN GENES IN THE STURGEON FISH (Acipensor transmontanus).
ENK are produced from a propeptide precursor, proenkephalin (proENK), which is translated from preproenkephalin mRNA that is encoded by a gene distinct from the other endogenous opioid peptides [19, 20].
To this end, the authors have made efforts to develop stratifying biomarkers to aid in the diagnostic and prognostic assessment of coronary artery disease, which have included copeptin (4), proenkephalin (PENK) (5), midregional proadrenomedullin (MR-proADM) (6), pro-substance P (pro-SP) (7), oxidized LDL (oxidized phosphatidylcholine, malondialdehyde-modified) (8, 9) and molecular forms of natriuretic peptide (10).
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