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P4HProlyl 4-Hydroxylase (enzyme)
P4HProviding for Health (international health initiative)
References in periodicals archive ?
Comparative proteomics of monocytes in relation to BMD was first reported in 2008 from premenopausal Chinese women with low versus high BMD condition, wherein two-dimensional electrophoresis was employed and 5 proteins were differentially abundant including Ras suppressor protein 1 (RSU1), gelsolin (GSN), and manganese containing superoxide dismutase (SOD2) which were upregulated, while glutathione peroxidase 1 (GPX1) and prolyl 4-hydroxylase b subunit (P4HB) were downregulated in low BMD condition [36].
Bulleid, "Intracellular retention of procollagen within the endoplasmic reticulum is mediated by prolyl 4-hydroxylase," The Journal of Biological Chemistry, vol.
Collagen prolyl 4-hydroxylases (P4Hs) are VitC-dependent enzymes that catalyze the proline hydroxylation in collagens.
Tasanen et al., "Molecular biology of prolyl 4-hydroxylase," Annals of the New York Academy of Sciences, vol.
Kivirikko, "Co-expression of the a subunit of human prolyl 4-hydroxylase with BiP polypeptide in insect cells leads to the formation of soluble and insoluble complexes: soluble a-subunit-BiP complexes have no prolyl 4-hydroxylase activity," Biochemical Journal, vol.
Production of stable recombinant collagen triple helix structure requires prolyl 4-hydroxylase enzyme (29) and P.pastoris expressing prolyl 4-hydroxylase enzyme is engineered to produce high (g/15/1-1) hydroxylated triple helixes of recombinant human collagen type I, II and III (8), (30).
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase.
ABSTRACT : Prolyl 4-hydroxylase (P4H) plays a central role in collagen synthesis by catalyzing the hydroxylation of the proline residue in the X-Pro-Gly amino acid sequence, and controls the biosynthesis of collagen that influences overall meat quality.
Beneficial effects of inhibitors of prolyl 4-hydroxylase in C[Cl.sub.4] induced fibrosis of liver in rats.
Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron.
Antibody Company Clone Dilution CAF phenotype-related proteins Podoplanin Abcam, Cambridge, UK 18H5 1:100 Prolyl 4-hydroxylase Abcam, Cambridge, UK Polyclonal 1:200 FAP[alpha] Abcam, Cambridge, UK Polyclonal 1:100 S100A4 Abcam, Cambridge, UK Polyclonal 1:100 PDGFR[alpha] Abcam, Cambridge, UK Polyclonal 1:100 PDGFR[beta] Abcam, Cambridge, UK Y92 1:100 NG2 Abcam, Cambridge, UK NG2 1:50 TABLE 2: Clinicopathologic characteristics of patients with phyllodes tumor.
Prolyl 4-hydroxylase and lysyl hydroxylase are known also to catalyze an uncoupled decarboxylation of 2-oxoglutarate in the absence of the peptide substrate.