PSAP

(redirected from Prosaposin)
Also found in: Wikipedia.
AcronymDefinition
PSAPPublic Safety Answering Point
PSAPPersonal Sound Amplification Product
PSAPPresentation Layer Service Access Point
PSAPParticipant Statistical Areas Program (US Census Bureau)
PSAPPedestrian Safety Action Plan (various locations)
PSAPProsaposin
PSAPParticle Soot Absorption Photometer
PSAPPresentation Service Access Point
PSAPPublic Service Access Point
PSAPProstate Specific Acid Phosphatase (prostate enzyme)
PSAPPersonnel Security Assurance Program
PSAPPharmacotherapy Self-Assessment Program
PSAPPublic Safety Answering Position
PSAPPrivate Sector Advisory Panel (ICAC)
PSAPProvisions pour Sinistres A Payer (French)
PSAPPriority Substances Assessment Program (Canada)
PSAPProspective Special Access Programs (USAF)
PSAPPower Sector Action Programme (Damascus, Syria)
PSAPProvincial Software Acquisition Program (Canada)
References in periodicals archive ?
Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.
de Oliveira et al., "Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin," Journal of Cell Biology, vol.
Isolation characterization and proteolysis of human prosaposin the precursor of saposins (sphingolipid activator proteins).
(2004) Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its auto-activation.
(1991) Secretion of sphingolipid hydrolase activator precursor, prosaposin. Biochem Biophys Res Commun 176: 668-674.
Prosaposin (PSAP) is a multifunctional protein encoded by a single-copy gene.
The evolutionary history of Prosaposin: Two successive tandem-duplication events gave rise to the four saposin domains in vertebrates.
When the researchers injected mice with tumor cells that were known to be highly metastatic but to which they had added prosaposin, lung metastases were reduced by 80%, lymph node metastases were completely eliminated, and survival time was significantly increased.
These mice lived 30% longer than mice not receiving prosaposin. The researchers believe that prosaposin stimulates tumor suppressor p53 activity in the connective tissue surrounding the tumor.
When scientists added prosaposin to metastatic tumour cells injected into mice, cancer spread to the lymph nodes was completely eliminated.
M19647) forward = GCACCGGCTT GTCAGTCAA, probe = CCCTCACC CTGACTAC, reverse = TCGGGTGTG GTTCCTCATG; prosaposin (GenBank accession no.
Proteolytic processing patterns of prosaposin in insect and mammalian cells.