Q-TWiST

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Acronym	Definition
Q-TWiST	Quality-Adjusted Time Without Symptoms of Disease or Toxicity of Treatment (statistical measure of the benefits of chemotherapy)

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QA-PFS and Q-TWiST analyses were calculated using EQ-5D-3L data as described in the poster.

Mean Q-TWiST analysis using all grade >=3 treatment-emergent adverse events (TEAEs) was significantly longer in the rucaparib arm than placebo for the ITT population (13.32 vs 6.44 months) and for patients with a BRCA mutation (16.42 vs 6.70 months).

In the analyses using TEAEs of interest (grade >=2 TEAEs of nausea, vomiting, fatigue, and asthenia), Q-TWiST was also longer in the rucaparib arm than placebo for the ITT population (13.16 vs 6.40 months) and for patients with BRCA mutation (16.24 vs 6.68 months).

Clovis Oncology Presents Patient-Centered Outcomes Data from Phase 3 ARIEL3 Study for Rubraca in Advanced Ovarian Cancer