OBJECTIVES: The objective of this work was to examine potential associations of biological end points with a set of physical and chemical properties describing inorganic metal ions present in exposures using QICAR.
CONCLUSION: QICAR has the potential to complement existing epidemiologic methods for estimating associations between CVDs and air pollutant exposures by providing clues about the underlying mechanisms that may explain these associations.
KEY WORDS: air pollution, cardiovascular disease, multipollutant, QICAR, QSAR.
A QICAR approach for quantifying binding constants for metal-ligand complexes.
Properties of metal ions included in the S3 QICAR analysis.
Quantitative ion character-activity relation-ships (QICARs) can be used to examine associations between biological end points and a set of physical and chemical properties describing inorganic metal ions present in exposures.
Using metalligand binding characteristics to predict metal toxicity: quantitative ion character-activity relationships (QICARs).