QOLRADQuality of Life in Reflux and Dyspepsia
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These values are higher than that reported in other validity-reliability studies on the QoLRAD questionnaire (7,11,19-24).
The use of PPI in some studies may have caused the test-retest results of the QoLRAD questionnaire to be higher than those of studies without PPIs.
In conclusion, the QoLRAD questionnaire, which measures quality of life in patients with GERD diagnosed by upper gastrointestinal endoscopy and/or 24-hour intraesophageal impedance-pH monitoring and performed at a clinic that is the third reference center, was found to be valid and reliable.
Psychometric validation of the German translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QoLRAD) questionnaire in patients with reflux disease.
Psychometric validation of the Hungarian translation of the gastrointestinal symptom rating scale (GSRS) and quality of life in reflux and dyspepsia (QoLRAD) questionnaire in patients with reflux disease.
[Psychometric validation of translation to Spanish of the gastrointestinal symptoms rating scale (GSRS) and quality of life in reflux and dyspepsia (QoLRAD) in patients with gastroesophageal reflux disease].
Changes in GIS or QOLRAD were tested against individual symptoms, diurnal distribution of the symptoms, the presence or absence of reflux, reflux medications, other GI medications, other synthetic medications as a collective group, family history of GI disease, Helicobacter infection, concurrent disease or irritants (alcohol, tobacco or spices).
The GIS and QOLRAD scores improved significantly by 41.9[+ or -]40.8% or 44.0[+ or -]40.7% (mean[+ or -]SD; C[I.sub.95] 31.2-56.5) and 50.7[+ or -]36.1% or 53.1[+ or -]35.1% (C[I.sub.95] 41.9-63.9), respectively (ITT or PP, both p < 0.001).
The frequency distributions of the outcome classes are listed in Table 2: 16, 18 and 26 patients rated the effectiveness of the treatment as very good or good on the GIS, QOLRAD (improvements >60%) and on the self-rated efficacy, respectively.
Only the use of spices (regularly used by two patients) had a significant effect, affecting the % change in QOLRAD significantly (p < 0.02; the % change in GIS was not significant (p = 0.168).
Efficacy self-rating scores correlated poorly with objective symptom scores or QOLRAD or with tolerability or taste.
Based on our data--% change in GIS or QOLRAD, or the absolute changes in scores--16 (GIS), 18 (QOLRAD) and 26 (self-rated efficacy) of the subjects had very good or good improvement.