QRDRQuinolone Resistance-Determining Regions
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QRDR analysis revealed the S83L substitution in the predicted DNA gyrase (GyrA) amino acid sequence of all genome sequencing isolates, in addition to S80L (Ab112 and Ab124) and S80Y (Ab107) substitutions in topoisomerase IV subunit (ParC).
Se han realizado estudios a nivel molecular de la enzima ADN girasa, la cual presenta dos subunidades de gyrA y dos subunidades de gyrB codificadas por los genes gyrA y gyrB respectivamente, y se determino que un mecanismo de resistencia de Neisseria gonorrhoeae involucra mutaciones en la Region Determinante de Resistencia a Quinolonas (QRDR) del gen gyrA de la ADN girasa, lo que produce proteinas alteradas que ya no podran ser ligadas a las quinolonas.
The quinolone resistant determining region (QRDR) is comprised of conserved area within gyrA and gyrB gene [26, 27].
coli isolates resistant and intermediate resistant to enrofloxacin were screened for mutations in the QRDR of the gyrA and parC genes and for the presence of plasmid-mediated quinolone resistance (PMQR) genes [qnrA, qnrB, qnrS, aaC(6)Ib, and qepA] by PCR, as previously described [6, 10, 16, 18, 24].
Some strains of Escherichia coli exhibit resistance to quinolone antibiotic due to any reasons like i) Mutations in the QRDR of gyrA and parC gene.
A second aim of the project was to investigate the mechanism of quinolone resistance by amplifying and sequencing the quinolone resistance determining region (QRDR) of the DNA gyrase A gene (gyrA).
The development of resistance to quinolones in bacterial populations associated with point mutations in the QRDR of parC should lead to the rapid spread of the corresponding nucleotide sequences in bacterial communities.
Relevant drug resistance genes bla TEM, bla, gyrA, gyrB, parC, parE, qnrS and qnrA were targeted and QRDR regions of gyrA, gyrB, parC, and parE were sequenced for mutations.
(51) Mutations within a highly conserved region of gyrA, the quinolone resistance-determining region (QRDR), are associated with the development of ofloxacin resistance in most resistant strains of M.
Before the emergence of bacterial plasmid-mediated quinolone resistance (PMQR) genes, research on the resistance mechanisms of (fluoro)quinolones were confined to mutations of chromosomal genes coding DNA gyrase or topoisomerase IV in the quinolone resistance determining region (QRDR) (Hopkins et al.