QSCSQuality Systems Certification Scheme
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In embryonal RMS, Pax3 is not associated with chromosomal translocation, but there are Pax3 3'UTR abnormalities including shorter transcript variants lacking miR-1/206-binding sites [70], escaping the miR-1/206-mediated Pax3 gene suppression as seen in the QSCs (Figure 2).
Because of the success of this effort, the QSCS created the WORC program after consulting with local residents.