QUADASQuality Assessment of Diagnostic Accuracy Studies (radiology)
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The results showed that race, sample type, sample size, and QUADAS scores were not the source of heterogeneity [all P > 0.05; [Table 2].{Table 2}
The QUADAS quality assessment of the individual study is presented in the Supplemental file (Table S1).
Finally, according the QUADAS criteria, all involved studies showed partial verification bias, differential verification bias, and incorporation bias.
Sensitivity analyses were performed to assess excluding studies with a high risk of verification bias according to QUADAS 2.
Since the QUADAS quality scores for the palpation articles were uniformly high (mean=11.8/13, s=0.94), it would have been fruitless to attempt interpreting results based on study quality.
Table 7 summarizes methodological recommendations for future early screening studies gleaned from all phases of this review, ranging from summaries from the general literature on disability screening as well as autism-specific screening to those generated from the probe questions adapted from the QUADAS system for evidence based analysis of diagnostic tests, to conclusions gleaned from these specific studies.
In addition, the 12 studies were scored by QUADAS by two independent reviewers.
The methodological quality assessment of each individual study on the basis of QUADAS is presented in Figure 1.
Emma McNally of the Royal College of Surgeons in Ireland, Dublin, and her associates performed this meta-analysis using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and QUADAS (Quality Assessment of Diagnostic Accuracy Studies).
Interrater reliability in assessing quality of diagnostic accuracy studies using the QUADAS tool: a preliminary assessment.