De Heer built a new cluster source and a quadrupole mass analyzer
with a range from 1-10,000 amu; clusters were ionized using a broadband UV arc lamp - all features that later proved to be essential for the discovery of electronic shell structure.
The mass spectrometer is a triple filter quadrupole mass analyzer
with a 0 - 300 AMU range.
One MS/MS system uses an ESI source to bring complete molecules into a quadrupole mass analyzer
. The mass specie of interest then goes on to a collision cell, where collisions with neutral gas atoms break up the macromolecules into smaller components.
The 7000A is heavily based on Agilent's 5975C GC/MSD in terms of both external feel, the interface for the user, the quartz quadrupole mass analyzer
and other internal components of the system.
The precursor ions then react with the sample in the flow tube, which in turn is fed into the secondary quadrupole mass analyzer
. This method is claimed to eliminate isobaric interfaces and has sensitivity down to 50 ppt, which is about 15 times better than the first generation Voice100.
One vendor that is on the verge of entering the portable GC/MS market is Microsaic, which has developed a quadrupole mass analyzer
on a chip that can be easily configured as a suitcase-sized GC/MS; it has been shown in such a configuration in the company's ChemPack instrument.
The system includes a front-end quadrupole mass analyzer
that enables tandem MS experiments, which Bruker refers to as "Mass Selective Ion Enrichment." Improvements over the previous model include mass accuracy in the sub-ppm range, a mass range of 100-10,000 Da and resolution of 900,000 FWHM with a 7 Tesla magnet and 1.5 million FWHM with a 9.4 Tesla magnet.
The APEX-Q uses a quadrupole mass analyzer
prior to the FT portion of the system, which enables it to run MS/ MS fractionation.