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References in periodicals archive ?
Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington's disease.
The induction of IDO and TDO leads to increased concentration of kynurenine pathway metabolites, mostly kynurenic acid and quinolinic acid.
Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease.
Quinolinic acid, a neuroactive metabolite of the kynurenine pathway, can induce the expression of several proinflammatory cytokines and chemokines.
They found that suicide attempters had more than twice as much quinolinic acid in their spinal fluid as the healthy people, which indicated increased glutamate signaling between nerve cells.
Within tryptophan catabolism, the kynurenine pathway works to form quinolinic acid (QUIN).
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Some neurologists surmise that HIV destroys nerve cells indirectly by prompting the overproduction of a brain chemical called quinolinic acid, which can cause toxic effects at high levels (SN: 3/7/92, p.
Earlier studies by these and other scientists showed that when quinolinic acid was injected into the brains of rats, it damaged only the same types of neurons as those in humans with HD.
Activation of certain cytokines (such as IL-6, IFN-y[gamma], TNF-[alpha], and LPS) can lead to activation of indoleamine 2, 3-dioxygenase (IDO), which shunts tryptophan down the kynurenine and quinolinic acid pathways, resulting in suboptimal serotonin levels.