Cell motility in chronic lymphocytic leukemia: defective Rap1
and [alpha]L[beta]2 activation by chemokine.
Epac1 Agonist Treatment Led to Increased Rap1
and Decreased p38 MAPK and JNK.
However, to validate our model, we only consider activity in the random AP1 (RAP1
) (accecibale by all the U[P.sub.i]), and assumed other optional AP's to be null.
In this paper, only the RAP1
and one MAP are adopted to compose the superframe in the beacon-enable mode.
Altman, "SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1
," Journal of Cell Science, vol.
Gene Primer (5' [right arrow] 3') Annealing temperature ([degrees]C) [beta]-Actin F CCTCATGCCATCCTGCGTCTG 58 R TTGCTCGAAGTCTAGGGCAACATAG TRF1 F AAGTCCTGAAAGCCCTGAATC 58 R TTCCTGTGCCTCCAAAATCT TRF2 F CTGTATTCATTTTGCTAACTTAG 55 R ATTCTTAACACTCTCTAGAGTTG TIN2 F CTTCATTCCTACTAAACTACTTG 57 R ACTGTAGAGACAGTTCTAGACCT POT1 F CAGAAAAGTGTGGATATG 55 R AAGTAAAAGAAGTGTGGG TPP1 F GCGTGACGTCTCACATCG 55 R ATCGTGATGGTTCTGCCTTC RAP1
F TGTGGTGTGTGTGTGTGTGG 50 R CCCCACACACACCACACAC Table 2: Clinical and demographic parameters of patients participating in the study.
Boyer, "Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1
in migrating NBT-II cells," Journal of Biological Chemistry, vol.
Various known tumor-associated genes (bcl2, MALT1 and DCC at 18q21; and RAP1
at 4q21) and a gene related to the embryogenesis of gonads such as H-Y regulator gene at Xp22.3 are located at or near the translocation breakpoints.
Washington, June 21 ( ANI ): Researchers have discovered that RAP1
, a gene that protects telomeres- the ends of chromosomes, has a key role in obesity.
The protein expressed by RAP1
gene is a small GTPases which belongs to the RAS super-family and shows 50% amino acid sequence homology with RAS (5).