RBE4Rat Brain Endothelial Cells
RBE4Rat Brain Microvessel Endothelial (cell)
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(a) In vitro Treatment Dose Duration Sulforaphane (SFN) 0.01-5 [micro]M 0-200 min Oleocanthal (Oleo) 0.5-50 [micro]M 72 h 1 [alpha],25-Dihydroxyvitamin 4 h or 24 h D3 (1,25[(OH).sub.2]D3) 1-100 nM 1 -3 days Fascalpsyn 1-100 [micro]M 24-48 h Treatment Cell line Sulforaphane (SFN) Brain capillaries Oleocanthal (Oleo) bEnd3 1 [alpha],25-Dihydroxyvitamin Brain capillaries D3 (1,25[(OH).sub.2]D3) RBE4 hCMEC/D3 Fascalpsyn LS-180 hGF Treatment Species Reference Sulforaphane (SFN) [Nrf2.sup.-/-] mouse [108] [p53.sup.-/-] mouse Oleocanthal (Oleo) Mouse [141] 1 [alpha],25-Dihydroxyvitamin Rat D3 (1,25[(OH).sub.2]D3) Rat [145] Human Fascalpsyn Human [147] (b) In vivo Treatment Dose Duration SFN 1-10 mg/kg intraperitoneal (i.p.) 2 days Verapamil 2-5 mg/kg i.p.
FACILITY LOCATIONS AND SQUARE FOOTAGE: RBE4 plant, Juarez, Mexico--240,000; ARD Logistics, Cottondale, Ala.--120,000
Ethanol potentiates lipopolysacchiaride- or interleukin-1-[beta]-induced nitric oxide generation in RBE4 cells.
Teixeira et al., "Flavonoid transport across RBE4 cells: a blood-brain barrier model," Cellular and Molecular Biology Letters, vol.