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RBP2Retinoblastoma Binding Protein 2
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2 COI 100 KM406728 (TSHB) EF-1[alpha] 100 KM406747 CAD 99 KM406713 16s mtDNA 98 KM406663 28s rDNA 99 KM406679 Fusarium AF-8 EF 100 KC691549 RBP1 100 KC691607 RBP2 100 KC691638 Fusarium AF-9 EF 99 KM406625 RBP1 100 KC691613 RBP2 100 KM406646 Table 3.
(2007) The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
LSD1 [18, 61] and RBP2 [20, 62] are pRB-interacting histone demethylases that catalyze the removal of methyl groups from H3K4me1/2 and H3K4me3, respectively.
The up-regulated genes include HIAP1, CRAF1, TRAF6, CASP1, CASP2, CASP3, CASP4, HPRT, GADD45, MCL-1, NIP1, BCL2L2, TRAP3, GSTP1, DAXX, PIG11, UBC, PIG3, PCNA, CDC10, JNK1 and RBP2. The down-regulated genes were TRAIL, TNFR, AP13, IGFBP3, SARP3, PKB, IGFBP, CASP7, CASP9, TNFSF6, TRICK2A, CAS, TRAIL-R2, RATS1, hTRIP, TNFb and TNFRSF5.
The RBP2 sequences had lengths of 763 bp in Rhapidophyllum hystrix (Fraser ex Thouin) H.
The side chain of Q108 hydrogen bonds the hydroxyl group of retinol in RPB1and RBP2, and the Q-H replacement at the position might have a functional significance (Folli et al., 2001, 2002).