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RBP3Retinol Binding Protein 3
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In addition, studies from our group showed that AIRE significantly up-regulated the mRNA expression levels of Ins2, glutamate decarboxylase 65/67 (GAD65/67), insulinoma-associated protein 2 (IA-2), IGRP, retinol-binding protein 3 (Rbp3), salivary protein 1 (Spt1), pyrin domain containing 5 (Nalp5), and mylin-oligodendrocyte glycoprotein (Mog) in AIRE-overexpressing bone marrow-derived dendritic cells (BMDCs), DC2.4 cells, and RAW264.7 cells.
It is noteworthy that the guanine nucleotide-binding protein (G protein) alpha-transducing activity polypeptide 2 (GNAT2) and retinol-binding protein 3 (RBP3) were jointly and significantly enriched in GO terms of sensory perception, cognition, and signaling by GPCR pathway.
In this network, the downregulated GNAT2 was a disease-related gene, and it was linked with RBP3 by the short-wave-sensitive opsin 1 (OPN1SW).