RCYPRadiant Child Yoga Program
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2 show that rCYP isoforms 1A2, 2C9, 2C19, 2E1 and 3A4 were inhibited by at least one of the kava test compounds, whereas isoforms 2A6 and 2D6 were not inhibited at 200 [micro]M, the highest concentration tested.
Desmethoxyyangonin demonstrated no inhibitory activity of 2C9 in the hepatocyte assay, but showed moderate inhibition of this isoform in the rCYP assay (I[C.sub.50] value of 50 [micro]M).
The compounds that produced the greatest effects on rCYP activity--kava root extract, methysticin, and desmethoxyyangonin--also produced the greatest effects on hepatocyte viability.