RFC1Reduced Folate Carrier 1
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References in periodicals archive ?
Torii et al., "Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma," Journal of Pediatric Hematology/Oncology, vol.
Allele frequencies obtained for the present study were MTHFR 677T (10%) and 1298 C (30%), TS 3UTR 0bp (46%), MDR1 3435T and 1236T (62%), RFC1 80A (57%), GGH 401T (61%), MS 2756G (34%), ATIC 347G (52%) and SHMT1 1420T (80%).
Comparison of our healthy subjects with Indian study from north India reveals that there was significant difference in the occurrence of GGH 401T, RFC1 80A and MDR1 1236T variant alleles.
There are differences in the occurrence of GGH 401T, RFC1 80A and MDR1 1236T variant alleles within Indian population.
Inhibition of the antiinflammatory effects of methotrexate by high-dose folinic acid likely results from decreased methotrexate uptake, since folinic acid and methotrexate compete for the same transporter (RFC1) for absorption from the gastrointestinal tract and for cellular uptake.
For example, Dervieux and coworkers suggested that combinations of functionally significant SNPs in RFC1, AICAR transformylase, and TS are more predictive of methotrexate response than any single SNP.
The method detects MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, MTRR 66A>G, CBS 844ins68, CBS 699C>T, BHMT 742G>A, RFC1 80G>A, TCII 67A>G, TCII 776C>G, PON1 163T>A, and PON1 575A>G.
RFLP analysis was used to identify BHMT 742G>A (35), CBS 699C>T (22), PON1 163T>A, PON1 575A>G, RFC1 80G>A (32), TCII 776C>G, and TCII 67A>G (29).
The genes they have looked at are involved in the intracellular transport (reduced folate carrier 1 or RFC1), and conversion ([gamma] glutamyl hydrolase or GGH) of methotrxate, metabolism of purine and pyrimidine (methylenetetrahydrofolate reductase or MTHFR, thymidylate synthase or TS, methionine synthase or MS, serine hydroxymethyltransferase I or SHMT 1 , aminoimidazol carboxamide ribinucleotide transformylase or ATIC, methionine synthase reductase or MTRR) and efflux of the drug (multidrug resistance protein 1 or MDR1).
Methotrexate is taken up from the gut and by cells via the reverse folate carrier 1 (RFC1).