RFC5

AcronymDefinition
RFC5Replication Factor C 5
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References in periodicals archive ?
In addition, we also found nine genes that play a central role in the upper progression path of Figure 1(a), i.e., two DNA repair-related genes (histone cluster 2 (H2be; HIST2H2BE) and replication factor C5 (RFC5)), four apoptosis-related genes (heat shock 27-kDa protein 1 (HSPB1), zinc finger protein 480 (ZNF480), tubulin alpha 1c (TUBA1C), and ribosomal protein L30 (RPL30)), and three metabolism-related genes (aldolase B (ALDOB), frequently rearranged in advanced T-cell lymphomas 2 (FRAT2), and tRNA methyltransferase 1 (TRMT1)).
In the hepatocarcinogenesis of PBC&PSC in Figure 4, we also identified ten genes having differences in expression between PBC&PSC and HCC, i.e., HIST2H2BE (p value [less than or equal to] 1.00 x [10.sup.-3]), RFC5 (p value [less than or equal to] 1.00 x [10.sup.-3]), TIMP1 (p value [less than or equal to] 1.00 x [10.sup.-3]), ZNF480 (p value [less than or equal to] 1.00 x [10.sup.-3]), H3F3A (p value [less than or equal to] 1.00 x [10.sup.-3]), RPL30 (p value [less than or equal to] 1.00 x [10.sup.-3]), FRAT2 (p value [less than or equal to] 1.00 x [10.sup.-3]), ALDOB (p value < 7.2 x [10.sup.-2]), IGF2 (p value < 1.07 x [10.sup.-1]), and RPL23A (p value [less than or equal to] 1.00 x [10.sup.-3]).
In Figure 3, we observed that in normal liver cells, ryanodine receptor 2 (RYR2) is activated to facilitate UBC to modulate two TFs (ETS1 and BPTF) in the WNT and MAPK signaling pathways to induce DNA repair through the mediation of RFC5, metabolism through the mediation of FRAT2, and autoimmune function through the mediation of MDC1 and H3F3A.
Furthermore, EGFR repressed TP53 through the mediations of RFC5 and HUWE1 in the MAPK signaling pathway.
Furthermore, we found seven genes in NAFLD&NASH pathogenesis and NAFLD&NASH-associated hepatocarcinogenesis that also played a central role in PBC&PSC pathogenesis and PBC&PSC-associated hepatocarcinogenesis, i.e., two DNA repair-related genes (HIST2H2BE and RFC5), two apoptosis-related genes (ZNF480 and RPL30), and three metabolism-related genes (ALDOB, FRAT2, and TRMT1).