RIG-I

AcronymDefinition
RIG-IRetinoic Acid-Inducible Gene I (protein)
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References in periodicals archive ?
RIG-I Deficiency Does Not Alter Antiviral Interferon and Inflammatory Cytokine Responses to Influenza Infection.
The IFN-[beta] and [lambda]2/3 response to flu infection was similar in RIG-I KO and WT mice.
In order to further examine the role of RIG-I pathway activation in the response to IAV infection, we next investigated whether depletion of MAVS, the RIG-I adaptor, affects the survival rate during IAV infection.
Lung expression of RIG-I and MDA5 was modestly upregulated following influenza infection in MAVS KO mice as compared with WT mice, suggesting that there was attempted compensation for MAVS KO by overexpression of RIG-I and MDA5.
Interferon and Inflammatory Response Genes Are Induced during IAV Infection Even in the Absence of RIG-I or MAVS.
The DEGs that distinctively changed in each strain only accounted for 17.7% (WT), 10.2% (RIG-I KO), and 8.9% (MAVS KO).
Loo et al., "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2," Proceedings of the National Academy of Sciences of the United States of America, vol.
Gack, "Conventional protein kinase C-[alpha] (PKC-[alpha]) and PKC-[beta] negatively regulate RIG-I antiviral signal transduction," Journal of Virology, vol.
Maharaj et al., "Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling," Immunity, vol.
Shin et al., "Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25 mediated antiviral signal transduction," Proceedings of the National Academy of Sciences of the United States of America, vol.
Seya, "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-[beta] induction during the early phase of viral infection," The Journal of Biological Chemistry, vol.
Shu, "TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination," Journal of Molecular Cell Biology, vol.