of skeletal muscles, the kidney, lung, intestines, liver, and brain was demonstrated to decrease tissue injury induced by IR (9-15).
Because of the similarities between the mechanisms of ischemia-reperfusion injury produced by RIPC
and those proposed for AKI after CPB, (17-19) we decided to test the hypothesis that RIPC
could prevent AKI in patients undergoing CABG surgery.
While the exact molecular mechanism of RIPC
is not yet fully understood, it is thought to be due to the release of circulating factors such as adenosine, bradykinin, and cannabinoids, which subsequently signal subcellular modulators such as nuclear factor-KB and nitric oxide [24, 29, 30].
Numerous studies have concerned about the mechanisms of these two noninvasive approaches.[sup],,, Currently, it is believed that both SevoPoC and early RIPC
could activate reperfusion injury salvage kinase (RISK) pathway, comprising phosphoinositide 3-kinase-protein kinase B/Akt and extracellular signal-regulated kinase 1 and 2, and Survivor Activating Factor Enhancement (SAFE) such as STAT3.[sup],,, However, there is little information on the mechanisms responsible for the cardioprotection by delayed remote ischemic preconditioning (DRIPC).
's cardioprotective effect has been seen in patients undergoing selective PCI, many clinical trials have examined whether RIPC
has a protective effect on these patients [8-11].
Kottenberg and coworkers13 reported RIPC
with isoflurane anesthesia attenuated myocardial injury in patients underwent CABG but not propofol.
) held a meeting Tuesday with the participation of representatives of 14
BAGHDAD / Aswat al-Iraq: As the international community moves forward with several rule of law initiatives in Iraq, the Rule of Law International Policy Committee (RIPC
) held a meeting today at UNAMI Headquarters in Baghdad with the participation of representatives of 14 countries, the United Nations, the World Bank and EUJUST LEX Iraq, the European Union Integrated Rule of Law Mission for Iraq.
Scores of vehicles participated in the car rally that started from Faizabad Chowk and culminated at Rawalpindi Islamabad Press Club (RIPC
) near Liaquat Bagh where the participants staged a protest demonstration.