RIPFResearch Institute of Pomology and Floriculture (Skierniewice, Poland)
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Primary outcome was the incidence of RILI, including acute RP and RIPF. We considered the Radiation Therapy Oncology Group (RTOG) scale [39] or National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) Version 4.03 scale [40] for the clinical grading of RILI (Table 1).
Five trials (n = 573 cases) reported incidence of RIPF, and three CHE were evaluated.
In this stage, berberine, LI, and TRQI significantly reduced the incidence of RIPF. TGF-[beta] decreased significantly after berberine, EI, and TRQI intervention; therefore the vicious cycle was broken.