RNAi


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AcronymDefinition
RNAiRibonucleic Acid Interference
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LIST OF FIGURES SUMMARY FIGURE GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, 2011-2018 ($ MILLIONS) 7 FIGURE 1 SIMPLIFIED SCHEMATIC REPRESENTATION OF THE RNAI MECHANISM 10 FIGURE 2 THERMO FISHER RNAI PRODUCT SELECTION 32 FIGURE 3 GLOBAL RNAI RESEARCH TOOL AND REAGENT MARKET, 2011-2018 ($ MILLIONS) 43 FIGURE 4 SCHEMATIC COMPOSITION OF STABLE NUCLEIC ACID LIPID PARTICLE TECHNOLOGY 55 FIGURE 5 MODIFICATIONS TO SIRNA BACKBONES AND BASES 59 FIGURE 6 PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER BACKBONE STRUCTURE 60 FIGURE 7 DESIGNING HIGHLY ACTIVE SIRNAS FOR RNAI THERAPEUTICS 85 FIGURE 8 ROSETTA GENOMICS PIPELINE 112
CHAPTER 2 SUMMARY 6 SUMMARY TABLE GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, THROUGH 2018 ($ MILLIONS) 7 SUMMARY FIGURE GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, 2011-2018 ($ MILLIONS) 7
CHAPTER 3 INTRODUCTION TO RNAI TECHNOLOGIES 9 OVERVIEW 9 RNAI DISCOVERY 10 RNAI GENE-SILENCING MECHANISM 10 FIGURE 1 SIMPLIFIED SCHEMATIC REPRESENTATION OF THE RNAI MECHANISM 10 MICRORNA 11 TABLE 1 MICRORNA DATABASES 12 TABLE 2 COMPUTATIONAL TOOLS FOR MIRNA TARGET PREDICTION 13 RNAI APPLICATIONS 13 RNAI RESEARCH TOOLS AND REAGENTS 13 RNAI DRUG DEVELOPMENT 13 RNAi Drug Delivery 14 Stability 14 Size Limitation 14 Cellular Uptake 15 Immune Response Activation 15 Targeting 15 RNAi Drug Design 15 RNAI DIAGNOSTICS: MICRORNA DIAGNOSTICS 16 RNAI IN AGRICULTURE 16 RNAI MARKET OVERVIEW 16 TABLE 3 GLOBAL PHARMACEUTICAL MARKET, MARKET SHARES BY REGION AND TOP COMPANIES (%/$ MILLIONS/$ BILLIONS) 17 RNAI AS A POSSIBLE TECHNOLOGICAL PREMATURITY 18 MERCK AND RNAI 18 Acquisition of Sirna Therapeutics 18
CHAPTER 6 RNAI LANDSCAPE 90 FUTURE TRENDS 90 WHAT IS RNA INTERFERENCE?
CHAPTER 7 RNAI DRUG DELIVERY-MARKET DATA 112 MARKET TRENDS 112 MARKET SIZE AND GROWTH 112 RNAI DRUGS 113 GLOBAL PHARMACEUTICAL MARKET 113 TABLE 24 GLOBAL PHARMACEUTICAL SALES AND FORECAST THROUGH 2018 ($ BILLIONS) 114 FIGURE 3 GLOBAL PHARMACEUTICAL SALES AND FORECAST, 2011-2018 ($ BILLIONS) 114 Pharmaceutical Growth Rates 114 Emerging Markets 115 TABLE 25 TOTAL UNAUDITED AND AUDITED GLOBAL PHARMACEUTICAL MARKET BY REGION, THROUGH 2017 ($ BILLIONS) 116 U.