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Various studies have shown the difference in RNFL thickness in diabetic patients, as compared to normal age matched population.9 Diabetic neuropathy is supposed to affect neurons, and thus, measurement of RNFL thickness in patients with DM can be utilized to diagnose patients with, or at risk for development of diabetic neuropathy.
The Heidelberg Spectralis (version 18.104.22.168; Heidelberg Engineering, Heidelberg, Germany) was employed to measure the macula and peripapillary RNFL (G: global, T: temporal, Ts: temporal superior, Ti: temporal inferior, N: nasal, Ns: nasal superior, Ni: nasal inferior).
Any of the following clinical findings in one or both eyes of an individual with an open angle can indicate a POAG suspect: (1) an appearance of the optic disc or RNFL that is suspicious for glaucomatous damage; (2) a visual field suspicious of glaucomatous damage in the absence of signs of other optic neuropathies; or (3) consistently elevated IOP associated with a normal appearance of the optic disc, RNFL, and visual field.
(13) reported a significant reduction in the overall and superior quadrant RNFL thickness in schizophrenia patients compared with controls.
The RNFL and the thickness of choroid tissue can be affected by obesity.
(14) Furthermore, studies have shown that patients with papilloedema show a thicker than normal RNFL, particularly in the nasal quadrant, whereas those with ONHD have normal RNFL thickness (15) (see Figure 1).
The objective of this study was to evaluate the peripapillary RNFL using SD-OCT in PEX patients and healthy subjects.
Fang Ko, M.D., from Moorfields Eye Hospital NHS Foundation Trust in the United Kingdom, and colleagues examined the potential of RNFL thickness in identifying those at increased risk of cognitive decline in the U.K.
RNFL thickness, MT and retinal vascularity were evaluated again after 12 months of treatment and any retinal IOP changes, were recorded.
Mean Anterior chamber depth (ACD) of patients was 3.41 +- 0.35 while mean RNFL appeared to be 103.26 +- 8.89 um.
The fact that there were no ocular, additional neurological or severe systemic diseases in the subjects which may effect the RNFL scores was taken into consideration.
According to the ophthalmological examination protocol, all patients were subjected to visual acuity test using Snellen chart; ocular tension measurement using Goldmann applanation tonometer; biomicroscopic examination; central 10-degree visual field test using Octopus 900 (Interzeag AG, Schlieren-Zurich, Switzerland); fundus autofluorescence photography and color fundus photograph examination using Visucam NM/FA (Carl Zeiss, Germany), and macular RGC-IPL thickness and peripapillary retinal nerve fiber layer (RNFL) thickness measurements using Cirrus high-definition OCT, model 5000 (Carl Zeiss Meditec Inc., Jena, Germany).
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