They assessed RNFLT
before and at 10 weeks and 6 months after laser therapy using time-domain (TD) OCT.
Furthermore, it is known that glaucomatous damage occurs preferentially in the temporal ONH quadrant  and tissue MBR of the temporal, superior, and inferior quadrants has been reported to be strongly associated with the RNFLT
in patients with glaucoma .
measurement can detect this neurodegenerative change at an early stage.
Mean peri-papillary RNFLT
of amblyopic eye and normal eyes were entered into the database.
and TMV metrics from OCT might reflect neurodegeneration on a more global level , thus supporting a possible association with walking impairment--another global manifestation of MS .
in subjects with MS without a history of ON is lower than in control subjects, indicating subclinical axonal loss [9,16].
In this study, sectorial thickness values of each retinal layer at macular level, circumpapillary RNFLt
of the optic nerve, and BMO-MRW were measured using SD-OCT Glaucoma Module Premium Edition (GMPE) software (Heidelberg Engineering, Germany) to assess the putative thickness differences between controls and initial glaucoma, controls and advanced glaucoma, and initial and advanced glaucoma.
Changes in BCVA and RNFLT
during the study period were not observed in any of the study groups.
The Spectralis OCT software, Heidelberg Explorer (HEE, version 5.3; Heidelberg Engineering Co., Heidelberg, Germany), was used for the automatic segmentation of the RNFL and for calculation of RNFLT
. Upper and lower boundary lines were artificially and automatically adjusted when misplaced.
Thus, the BMO-MRW was demonstrated to have a stronger association with visual field sensitivity than other parameters [18, 19] and comparable accuracy for the discrimination of pre- and perimetric glaucomatous eyes using the RNFLT
However, even with a faster image acquisition (approximately 2 seconds), RNFL thickness (RNFLT
) measurements may be affected by artifacts and misalignments (MAs), which may occur as a result of eye or head movements .
Clinical findings also included retinal nerve fiber layer thickness (RNFLT
) and ganglion cell complex thickness (GCCT) in the CPB and macular areas, best-corrected visual acuity (BCVA), mean deviation (MD), and refractive error.