RORLRadiation Oncology Research Laboratory (University of Maryland at Baltimore)
RORLRail Operations Recruitment Limited (UK)
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References in periodicals archive ?
Functional ROR1 ligands have remained unknown, though secreted proteins of the wingless-type MMTV integration site(Wnt) family have recently been proposed as ligand candidates (3), (4) and Wnt5a was shown to bind Rorl (5).Ten years after identification of ROR1 (1), gene expression profiling of B cell malignancies on a genomic scale displayed RORI overexpression in leukemic B cells of Chronic Lymphocytic Leukemia (CLL) (6), (7)
Recently, two studies have separately demonstrated that Rorl protein is uniformly expressed in all CLL samples independent of molecular and clinical heterogeneity or mutational status, whereas normal B cells, other normal blood cells, and normal adult tissues do not express cell surface Rorl (11), (13).