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Supplementary Figure 8: time-dependent and gene-specific modulation of the bile acid-related transcriptome in RPTEC treated with EPA and DHA.
Human colon carcinoma cells (Caco-2, (a)), enterocytes in primary culture (InEpC, (b)), or renal proximal tubules epithelial cells (RPTEC, (c)) were cultured in the presence of eicosapentaenoic (EPA) (50 [micro]M) and docosahexaenoic (DHA) acids (25 or 50 [micro]M) for 12 (c) or 24 H (a, b).
Zeocin treatment of renal proximal tubular epithelial cells (RPTEC) was found to increase up to 10-fold (for 400 ng/ml Zeocin) the number of TNTs formed by these cells .
(2011) Human proximal Same cells tubular epithelial cells (RPTEC) Wang et al.
The renal proximal tubule epithelial cells (RPTECs) are primarily responsible for renal solute reabsorption and metabolism end-product excretion.
Therefore, the mRNA expression of multiple xenobiotic transporters, typically expressed in RPTECs, was compared in proliferating 2D and differentiated 2D, 2.5D, as well as 3D RPTEC/TERT1 cells (Fig.
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