RPXR

AcronymDefinition
RPXRRat Pregnane X Receptor (molecular cloning)
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References in periodicals archive ?
Here we report that BPA is a potent agonist for hPXR but not for mouse or rat PXR (mPXR and rPXR, respectively).
To determine whether BPA acts specifically on hPXR, we evaluated the ability of BPA to activate a number of other nuclear receptors, including rPXR, human retinoid acid receptor (RAR)a, retinoid X receptor (RXR), farnesoid X receptor (FXR), liver X receptor (LXR)a, peroxisome proliferator-activated receptor (PPAR)a, PPARy, vitamin D receptor (VDR), and ERa (Figure ID).
We found that BPA is a potent agonist for hPXR but not for mPXR and rPXR. We further identified the key residues within PXR's ligand-binding pocket interacting with BPA by combining analyses of computational docking and site-directed mutagenesis.