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(2) Statistics should include Rhinitis Quality of Life Questionnaire scores (RQLQ), Rhinitis Total Symptom Scores (RTSS), and/or specific serum IgE level.
SLIT tablets combine two major species together and may better target allergic diseases with high heterogeneity such as AR. In addition, SLIT tablets ensure better modulation of the drug amount and higher compliance than SLIT drops due to its safety and convenience for transportation, administration, and follow-up. A majority of current RCTs showed some benefit from immunotherapy on RQLQ and RTSS.
The relationships of RQLQ and VAS scores with the sonoelastographic measurements were evaluated.
The median RQLQ scores were 3.39 points (IQR=1.93, range 1.68-5.43).
Values analyzed were the mean RQLQ scores in each of the 7 domains and the overall composite scores.
Following treatment, clinically and statistically significant improvements in mean composite RQLQ scores were seen in both the Dead Sea saline group and the corticosteroid group; no significant improvement occurred in the control group (table).
Overall, improvements in RQLQ scores were 1.4-fold greater than the MID value.
* OUTCOMES MEASURED The RQLQ score was the primary outcome.
The RQLQ scores were similar in the 2 groups initially.
Outcomes measured Primary outcomes were the severity of total and individual nasal symptoms evaluated by both the clinician and patient using a visual analog scale; overall response to therapy; and the patient score on the RQLQ. Adverse treatment effects of loratadine and FNS were reported as secondary outcomes.
Patient-rated RQLQ scores showed no improvement with loratadine alone compared with placebo but statistically significant improvement with both FNS and FNS plus loratadine (P [is less than] .05).
In the RQLQ, descriptive statistics were used to evaluate differences among treatment groups for baseline scores, and descriptive and inferential statistics were used to compare the mean change from baseline RQLQ scores among and between the four treatment groups.
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