RRM1Ribonucleotide Reductase, M1 Subunit
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Nuclear (ERCC1) and cytoplasmic (RRM1) expression of the biomarkers was measured with immunohistochemical staining.
Phosphorylation at the RRM1 domain of hnRNPA1 by S6K2 selectively promotes association of Bcl-xL or XIAP with hnRNPA1 and exports the RNA-protein complex into the cytoplasm.
RT PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC.
However, as demonstrated from the multitude of clinical studies, quantitative analysis of RRM1, ERCC1, and BRCA1 mRNA expression levels has been performed mainly on tumor specimens obtained from fiberoptic bronchoscopy biopsy or surgical resection.
Ribonucleotide reductase subunit M1 (RRM1), a tumor-suppressor gene also involved with DNA synthesis and repair, also appears to impact the effectiveness of gemcitabine chemotherapy.
(40) Immunohistochemical analyses revealed that elevated tumor expression of the proteins encoded by 2 genes, ERCC1 and RRM1, was associated with poor prognosis (41); these genes may serve as potential biomarkers for personalized chemotherapy.
Quantitative gene expression assays for excision repair (ERCC1), thymidine phosphorylase (TYMP), stathmin (STMN1), ribonucleotide reductase (RRM1) and other genes provide valuable information to help predict chemotherapy responses.
: ABSTRACTObjective We conducted a perspective study to investigate the association between mRNA expression quantities of ERCC1 BRCA1 RRM1 and RRM2 and response to chemotherapy and clinical outcome of advance Non-Small Cell Lung Cancer.(NSCLC).Methods: Two hundred eight patients who were diagnosed as advanced stage NSCLC were included in our study.