RRM2

AcronymDefinition
RRM2RNA (Ribonucleic Acid) Recognition Motif 2
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In addition, phosphorylation of IGF2BP2 in the linker region between RRM2 and KH1 by mTOR promotes its binding to the IGF leader 3 mRNA 5r-UTR, enhancing the initiation of IGF2 translation through eIF-4E- and 5f cap-independent internal ribosomal entry [49].
The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells
The suppression is relieved by sumoylation of the RRM2 domain of hnRNPA1, resulting in the decreased affinity of hnRNPA1 to protein and translocation into the nucleus [67].
Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression
A fluorescence-based and real-time detection method was used to determine the relative cDNA quantification for ERCC1 BRCA1 RRM1 and RRM2 and AY-actin was used as the reference gene.
The standardized mRNA quantification amount of ERCC1 BRCA1 RRM1 and RRM2 was as- sessed by comparing the target amount of AY-action amount.
However we did not find the low level of RRM1 (OR=1.43 95%CI=0.79-2.57) and RRM2 (OR=1.13 95%CI=0.63-1.13) mRNA expres- sion has a role on the response to platinum-based chemotherapy.
How- ever no association was found between RMM1 and RRM2 mRNA expression and prognosis of NSCLC.
Table-II: ERCC1 BRCA1 RRM1 and RRM2 mRNA expression and response to chemotherapy.
High RRM2 2.450.32###42###48.3###62###51.2###-###1.0(Ref.)
Recently several studies reported the association between ERCC1 BRCA1 RRM1 and RRM2 mRNA expression and clinical outcome of NSCLC.38-13 Zhang et al.
Table-III: ERCC1 BRCA1 RRM1 and RRM2 mRNA expression and overall survival of advanced NSCLC
The relatively sample size may be the reason that no association was found between RRM1 and RRM2 mRNA expression and clinical outcome of NSCLC patients.
ERCC1 and BRCA1 mRNA expression predicts the clinical outcome of non-small cell lung cancer receiving platinum-based chemotherapy
The researchers created the particles from two polymers plus a protein that binds to receptors on the surface of cancer cells and pieces of RNA called small-interfering RNA, or siRNA, designed to stop the RRM2 gene from being translated into protein.
Cancer genes switched off in humans
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