RS3PERemitting Seronegative Symmetrical Synovitis with Pitting Edema
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This rapid response to the corticosteroid therapy verified our RS3PE syndrome diagnosis.
The differential diagnosis of RS3PE syndrome includes rheumatoid arthritis (RA), complex regional pain syndrome, gout arthritis, systemic lupus erythematosus (SLE), systemic sclerosis, overlap syndrome, mixed connective tissue disease, polyarteritis nodosa, amyloidosis, pseudogout disease, and carpal and tarsal tunnel syndromes.
We should always keep the possibility of RS3PE in all elderly patients presented with acute onset polysynovitis and pitting edema.
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome, secondary to NonHodgkin lymphoma.
After vascular compromise was excluded, he was referred to the rheumatologists where the clinical diagnosis of RS3PE was made and prednisone 15 mg was commenced with immediate reduction in swelling.
In 1985, McCarty first described RS3PE in JAMA [1].
Another important characteristic of RS3PE syndrome is its association with neoplastic and rheumatologic diseases (3, 5).
(6) evaluated 27 cases with RS3PE retrospectively in 1997 and established the following diagnostic criteria for the disease:
"Remitting seronegative symmetrical synovitis with pitting edema" (RS3PE), PMR ile ayirici taniya giren ilgi cekici bir inflamatuvar romatizmal hastaliktir.