RSK1Ribosomal S6 Kinase 1
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RSK1 and RSK2 have been proven critical to the survival of patients with TNBC.
Extensive lists of GSK-3 substrates or GSK-3 binding proteins have been reported and include amyloid precursor protein, APC, ATP-citrate lyase, axin, axil, [beta]-catenin, c-jun, Jun B, Jun D, Ci155, C/EBP alpha, CRMP2, CRMP4, CREB, CTP, cyclin D1, dystrophin, eIF2B, glycogen synthase, glucocorticoid receptor, heat shock factor 1, hnRNP, K-casein, KRP, MAB 1B, MAP 2, MAP 2C, MITF, c-Myc, L-Myc, alpha NAC nascent polypeptide-associated complex, NCAM, NDRG1, NDRG2, neurofilament L, neurofilament M, neurofilament H, Notch 1C, p21 CIP1, p53, presenilin, pyruvate DH, PP1 G-subunit, protein phosphatase inhibitor 2, stathmin, synphilin-1, RSK1, and Tau ( and http://
ERK3 gene and protein levels were increased at most arsenic doses and time points tested (Figure 4A), whereas RSK1, PKAC[alpha], and PKB[alpha]/aktl all showed consistent decreases in expression following arsenic exposure in both assays (Figure 4B-D).