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References in periodicals archive ?
elegans: Caenorhabditis elegans; CGC: Caenorhabditis Genetics Center; Daf: dauer formation-defective; DCR: Dicer related; Dpy: dumpy; DRH: Dicer related helicase; eak: enhancers of akt-1; egl: egg-laying defective; EMS: ethylmethane-sulfonate; fox: Feminizing gene on X; GFP: green fluorescent protein; GWAS: genome-wide association study; KO: knockout; lin: abnormal cell lineage; mec: mechanosensory abnomarity; PCR: polymerase chain reaction; PIR: phosphatase interacting with RNA/RNP; PS: phosphatidylserine; RFP: red fluorescent protein; RNAi: RNA interference; rSNP: regulatory single nucleotide polymorphism; scrm: SCRaMblase (phospholipid scramblase); sem: sex muscle abnormal; sid: systemic RNA interference defective; tat: transbilayer amphipath transporters; Unc: uncoordinated movement.
Many such noncoding SNPs that reside in the noncoding sequences (e.g., promoters, enhancers, and 3' termini) surrounding protein coding genes have been shown to have profound effects on the expression of neighboring genes and can cause disease phenotypes [3,4] and are thus called regulatory SNPs (rSNPs) [5, 6].
In this review, we summarize data accumulated in the past 13 years on the association of the Ecadherin -160C/A SNP with human conditions and highlight the important function of rSNPs as a risk factor for diseases.