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For comparing with RSTD , we also use the difference of L and S in successive iterations against a certain tolerance as the stopping criterion.
The results demonstrate that our proposed algorithm MALM-TR outperforms RSTD on either efficiency or accuracy.
We add different percent of random impulsive noise to the image and compare MALM-TR with RSTD. The results produced by both algorithms are shown in Figure 1.
We test our algorithm using an example from  and compare with RSTD .
Then we compare the proposed method with RSTD algorithm using RSE as the criterion.
From data in the table, it is observed that the RSEs obtained by MALM-TR and RSTD are much smaller than the unrecovered data, which means that both algorithm can improve the quality of the corrupted data.
 Nonstandard abbreviations: MPS, massively parallel sequencing; cff, cell-free fetal; RSTD, relative sequence tag density; NGS, next generation sequencing.
For Helicos, our data showed 1 D21 sample, with the overall lowest amount of reads, to have the lowest RSTD ratio, but overall we observed no correlation between RSTD ratio and the number of uniquely mapped reads on either platform [Helicos, Spearman r = -0.088 (95% CI -0.532 to 0.394) P = 0.7210 and Illumina, Spearman r = -0.232, 95% CI -0.629 to 0.263) P = 0.3401].
For the noninvasive detection of fetal T21, RSTD ratios for all 19 maternal plasma samples are shown per chromosome for each NGS platform (Fig.
Our data show RSTD ratios for T21 samples in a range of 1.04-1.11 for Helicos and a range of 1.03-1.12 for Illumina.
(21), which uses read counts to calculate ratios of RSTD. Samples can be normalized against averaged normalized RSTD from both adult male plasma controls (Fig.
 Nonstandard abbreviations: T21, trisomy 21; CVS: chorionic villus sampling; cff cell-free fetal; NGS, next-generation sequencing; D21, disomy 21; RSTD, relative sequence tag density.
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- RST segment
- Rsts Extended