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The shifting in dominance from RSV-A to RSV-B every 2 years was repeatedly observed in our study and others (25).
Although RSV-A cases outnumbered RSV-B in our study, we did not determine the reason for this finding, whether RSV-A caused more symptomatic illness or transmitted more quickly than RSV-B among children.
We assigned 2013-14 as an RSV-B-dominant season for the purposes of modeling, although the numbers of RSV-A and RSV-B cases were almost equal.
Rhinovirus alone was associated with a lower chance of being hospitalized 3 or more days compared with RSV-A or RSV-B alone (OR 0.4).
Major Finding: Of 564 children infected with rhinovirus, 70% had RSV coinfection Rhinovirus alone was associated with a lower chance of being hospitalized 3 or more days compared with RSV-A or RSV-B alone (odds ratio 0.4).
RSV-A exhibited more genetic diversity than RSV-B. This difference may reflect sampling bias because more RSV-A sequences originating from diverse locations and years were available; however, the greater genetic diversity of RSV-A compared with RSV-B has also been observed in a study conducted in South Korea (10).
Estimated mean nucleotide and amino acid identities of 170 unique respiratory syncytial virus fusion gene sequences * Mean nucleotide Sequence identity, % [+ or -] SD Overall, n = 170 89.59 [+ or -] 8.38 RSV-A (within group), n = 105 97.06 [+ or -] 1.33 RSV-B (within group), n = 65 98.65 [+ or -] 0.69 RSV-A vs.
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- RSV LRI
- RSVP Application Programming Interface
- RSVP Integrated Multicast